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The gut lining can take a beating during extended use of GLP-1 class medications, and some researchers believe that supporting gut integrity proactively leads to better long-term tolerance

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In big systematic reviews of studies that include these and higher doses, daily intake above 200mg has often shown a decrease in efficacy that researchers call a U-shaped curve.24 That means, for the average person, taking more than 200mg could potentially work against their goals

But change takes time